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WHAT ANATOMIC FEATURES GOVERN PERSONAL LONG-TERM HEALTH RISKS FROM BREAST CANCER RADIOTHERAPY?
Kundrát, Pavel; Simonetto, Cristoforo; Eidemüller, Markus; Remmele, Julia; Rennau, Hannes; Sebb, Sabine; Wolf, Ulrich; Hildebrandt, Guido.
Affiliation
  • Kundrát P; Institute of Radiation Medicine, Department of Radiation Sciences, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
  • Simonetto C; Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Na Truhlárce 39/64, 18000 Prague, Czech Republic.
  • Eidemüller M; Institute of Radiation Medicine, Department of Radiation Sciences, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
  • Remmele J; Institute of Radiation Medicine, Department of Radiation Sciences, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
  • Rennau H; Department of Radiation Oncology, Leipzig University, Stephanstraße 9a, 04103 Leipzig, Germany.
  • Sebb S; Department of Radiation Oncology, University of Rostock, Südring 75, 18059 Rostock, Germany.
  • Wolf U; Department of Radiation Oncology, University of Rostock, Südring 75, 18059 Rostock, Germany.
  • Hildebrandt G; Department of Radiation Oncology, Leipzig University, Stephanstraße 9a, 04103 Leipzig, Germany.
Radiat Prot Dosimetry ; 186(2-3): 381-385, 2019 Dec 31.
Article in En | MEDLINE | ID: mdl-31711194
ABSTRACT
Breast cancer radiotherapy may in the long term lead to radiation-induced secondary cancer or heart disease. These health risks hugely vary among patients, partially due to anatomy-driven differences in doses deposited to the heart, ipsilateral lung and contralateral breast. We identify four anatomic features that largely cover these dosimetric variations to enable personalized risk estimates. For three exemplary, very different risk scenarios, the given parameter set reproduces 63-74% of the individual risk variability for left-sided breast cancer patients. These anatomic features will be used in the PASSOS software to support decision processes in breast-cancer therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiotherapy Planning, Computer-Assisted / Breast / Breast Neoplasms / Radiotherapy, Intensity-Modulated / Organs at Risk / Heart / Lung Type of study: Etiology_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Radiat Prot Dosimetry Year: 2019 Document type: Article Affiliation country: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiotherapy Planning, Computer-Assisted / Breast / Breast Neoplasms / Radiotherapy, Intensity-Modulated / Organs at Risk / Heart / Lung Type of study: Etiology_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Radiat Prot Dosimetry Year: 2019 Document type: Article Affiliation country: Alemania