Lovastatin Prevents Depressive Behaviors and Increased Hippocampal Neurogenesis in Streptozotocin-Induced Diabetic Mice.
Pharmacology
; 105(5-6): 339-348, 2020.
Article
in En
| MEDLINE
| ID: mdl-31722363
ABSTRACT
Depression is a progressive and chronic syndrome and commonly related to several neuropsychiatric comorbidities, of which depression is the most studied. Population-based studies have suggested a positive role of statins in ameliorating depression risk. However, the role of statins in the treatment of diabetes-related depression has not been well examined. Herein, we investigated the effects of lovastatin (LOV) on depressive phenotypes in streptozotocin-induced diabetic mice. The data suggested that the treatment of LOV at 10 or 20 mg/kg for 3 weeks markedly prevented diabetes-associated depressive behaviors reflected by better performance in the sucrose preference test, tail suspension test, and novelty-suppressed feeding test. The study further showed that these treatments improved the hippocampal neurogenesis as evidenced by increased bromodeoxyuridine-positive cells in the dentate gyrus with higher expression of mature brain-derived neurotrophic factor and increased phosphorylation of cAMP-response element-binding protein. As expected, diabetic mice treated with LOV showed significant improvement of hyperlipidemia rather than hyperglycemia. These results suggest that LOV may be employed as a drug for the treatment of diabetes-related depression.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lovastatin
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Depression
/
Diabetes Mellitus, Experimental
/
Neurogenesis
/
Hippocampus
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Pharmacology
Year:
2020
Document type:
Article
Affiliation country:
China