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Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia.
Ulloa, Erlinda R; Singh, Kavindra V; Geriak, Matthew; Haddad, Fadi; Murray, Barbara E; Nizet, Victor; Sakoulas, George.
Affiliation
  • Ulloa ER; Collaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.
  • Singh KV; Division of Infectious Disease, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Geriak M; Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Haddad F; Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Murray BE; Sharp Memorial Hospital, San Diego, California, USA.
  • Nizet V; Sharp Grossmont Hospital, La Mesa, California, USA.
  • Sakoulas G; Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Clin Infect Dis ; 71(6): 1413-1418, 2020 09 12.
Article in En | MEDLINE | ID: mdl-31773134
ABSTRACT
Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Bacteremia Type of study: Prognostic_studies Limits: Animals Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2020 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Bacteremia Type of study: Prognostic_studies Limits: Animals Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2020 Document type: Article Affiliation country: Estados Unidos