Internet-based cognitive behavioral therapy aimed at alleviating treatment-induced menopausal symptoms in breast cancer survivors: Moderators and mediators of treatment effects.
Maturitas
; 131: 8-13, 2020 Jan.
Article
in En
| MEDLINE
| ID: mdl-31787152
ABSTRACT
OBJECTIVES:
Results from our recently conducted randomized controlled trial (RCT) indicated that Internet-based cognitive behavioral therapy (iCBT), with or without therapist support, is effective in reducing the perceived impact of hot flushes and night sweats (HF/NS) and overall levels of menopausal symptoms in breast cancer survivors with treatment-induced menopausal symptoms. STUDYDESIGN:
We used data of 235 women and compared the iCBT groups combined (nâ¯=â¯156) with the control group (nâ¯=â¯79). Bootstrapped multiple regression analyses with interaction terms (group x potential moderator) or indirect effects (mediation pathway) were conducted. MAIN OUTCOMEMEASURES:
Reductions in perceived impact of HF/NS and overall levels of menopausal symptoms.RESULTS:
Women with lower levels of education benefited most from the iCBT. Age, time since diagnosis, current endocrine treatment, oophorectomy, frequency of HF/NS, and psychological distress did not moderate the treatment effects. Factors that mediated treatment effects were the development of healthier beliefs about experiencing hot flushes in a social context, about the impact of night sweats on sleep and daily functioning, and about the ability to control and cope with hot flushes. The acquisition of behavioral coping strategies and decreased psychological distress did not mediate treatment effects.CONCLUSION:
The results suggest that women with lower levels of education may benefit most from the current iCBT program, with or without therapist support. The development of healthier HF/NS beliefs contribute significantly to the observed positive effect of iCBT on the burden of menopausal symptoms. CLINICAL TRIAL INFORMATION NCT02672189.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Menopause
/
Cognitive Behavioral Therapy
/
Hot Flashes
Type of study:
Clinical_trials
/
Diagnostic_studies
Aspects:
Patient_preference
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Maturitas
Year:
2020
Document type:
Article
Affiliation country:
Países Bajos