Combination of a novel microtubule inhibitor MBRI-001 and gemcitabine synergistically induces cell apoptosis by increasing DNA damage in pancreatic cancer cell lines.

Liu, Yuqian; Zang, Ruochen; Li, Feifei; Shi, Chuanqin; Zhao, Jianchun; Zhong, Lili; Wang, Xin; Yang, Jinbo; Li, Wenbao

Liu, Yuqian; Zang, Ruochen; Li, Feifei; Shi, Chuanqin; Zhao, Jianchun; Zhong, Lili; Wang, Xin; Yang, Jinbo; Li, Wenbao.

Affiliation

Liu Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Zang R; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Li F; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Shi C; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Zhao J; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Zhong L; Marine Biomedical Research Institute of Qingdao, Qingdao, 266071, China.
Wang X; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Yang J; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Li W; Marine Biomedical Research Institute of Qingdao, Qingdao, 266071, China.

Invest New Drugs ; 38(5): 1207-1217, 2020 10.

Article in En | MEDLINE | ID: mdl-31802375

Subject(s)
Key words

Apoptosis; DNA damage; Gemcitabine; MBRI-001; Pancreatic cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Deoxycytidine / Tubulin Modulators / Diketopiperazines / Antimetabolites, Antineoplastic Limits: Animals / Female / Humans Language: En Journal: Invest New Drugs Year: 2020 Document type: Article Affiliation country: China

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