Perfusion in bone marrow lesions assessed on DCE-MRI and its association with pain in knee osteoarthritis: a cross-sectional study.
Skeletal Radiol
; 49(5): 757-764, 2020 May.
Article
in En
| MEDLINE
| ID: mdl-31820043
ABSTRACT
OBJECTIVE:
To investigate the association between pain and perfusion in bone marrow lesions with and without cysts assessed dynamic contrast-enhanced (DCE)-MRI in patients with knee osteoarthritis. SUBJECTS ANDMETHODS:
In a cross-sectional setting, perfusion in bone marrow lesions was assessed using 3 Tesla MRI and correlated (Spearman's rank correlation) to pain using the knee injury and osteoarthritis outcome score (KOOS). Bone marrow lesions were assessed across the whole knee with DCE-MRI using heuristic variable and non-contrast-enhanced-MRI using MRI osteoarthritis knee score.RESULTS:
Data were available from 107 participants. The participants had a mean age of 60.8 years, mean BMI of 34.5 kg/m2, mean KOOS-pain of 63.7 (0-100 scale), and mean bone marrow lesion sum score of 6.5 (0-45 scale). The bivariate association between KOOS-pain and the heuristic perfusion variable time to peak in bone marrow lesions containing subchondral cysts showed a statistically significant correlation (r = 0.40; p = 0.002). The perfusion variables were not correlated with KOOS-pain in bone marrow lesions without cysts.CONCLUSION:
In this cross-sectional study, the rate of perfusion (TTP) in bone marrow lesions containing subchondral cysts was associated with pain in patients with knee OA. DCE-MRI has a potential to be used for separating subtypes of OA.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain
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Bone Marrow
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Bone Marrow Diseases
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Magnetic Resonance Imaging
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Image Enhancement
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Contrast Media
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Osteoarthritis, Knee
Type of study:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limits:
Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Skeletal Radiol
Year:
2020
Document type:
Article
Affiliation country:
Dinamarca
Country of publication:
ALEMANHA
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ALEMANIA
/
DE
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DEUSTCHLAND
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GERMANY