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CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging.
Rui, Yun-Feng; Chen, Min-Hao; Li, Ying-Juan; Xiao, Long-Fei; Geng, Peng; Wang, Pei; Xu, Zheng-Yuan; Zhang, Xuan-Pu; Dai, Guang-Chun.
Affiliation
  • Rui YF; Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
  • Chen MH; Orthopaedic Trauma Institute, Southeast University, Nanjing, China.
  • Li YJ; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
  • Xiao LF; School of Medicine, Southeast University, Nanjing, China.
  • Geng P; China Orthopedic Regenerative Medicine Group, Hangzhou, Zhejiang 310000, China.
  • Wang P; Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
  • Xu ZY; Orthopaedic Trauma Institute, Southeast University, Nanjing, China.
  • Zhang XP; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
  • Dai GC; School of Medicine, Southeast University, Nanjing, China.
Stem Cells Int ; 2019: 6257537, 2019.
Article in En | MEDLINE | ID: mdl-31827530
ABSTRACT
Aged tendon-derived stem/progenitor cells (TSPCs) lead to age-related tendon disorders and impair tendon healing. However, the underlying molecular mechanisms of TSPC aging remain largely unknown. Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging. CTGF protein and mRNA levels were markedly decreased in the aged TSPCs. Moreover, recombinant CTGF attenuates TSPC aging and restores the age-associated reduction of self-renewal and differentiation of TSPCs. In addition, cell cycle distribution of aged TSPCs was arrested in the G1/S phase while recombinant CTGF treatment promoted G1/S transition. Recombinant CTGF also rescued decreased levels of cyclin D1 and CDK4 and reduced p27kip1 expression in aged TSPCs. Our results demonstrated that CTGF plays a vital role in TSPC aging and might be a potential target for molecular therapy of age-related tendon disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Stem Cells Int Year: 2019 Document type: Article Affiliation country: China
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Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Stem Cells Int Year: 2019 Document type: Article Affiliation country: China