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Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production.
Lau, Anthony; Avery, Danielle T; Jackson, Katherine; Lenthall, Helen; Volpi, Stefano; Brigden, Henry; Russell, Amanda J; Bier, Julia; Reed, Joanne H; Smart, Joanne M; Cole, Theresa; Choo, Sharon; Gray, Paul E; Berglund, Lucinda J; Hsu, Peter; Wong, Melanie; O'Sullivan, Michael; Boztug, Kaan; Meyts, Isabelle; Uzel, Gulbu; Notarangelo, Luigi D; Brink, Robert; Goodnow, Christopher C; Tangye, Stuart G; Deenick, Elissa K.
Affiliation
  • Lau A; Immunity and Inflammatory Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
  • Avery DT; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Jackson K; Immunity and Inflammatory Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
  • Lenthall H; Immunity and Inflammatory Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
  • Volpi S; Immunity and Inflammatory Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
  • Brigden H; Clinica Pediatrica e Reumatologia, Centro per le malattie Autoinfiammatorie e Immunodeficienze, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini and Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili (DINOGMI), Univer
  • Russell AJ; Immunity and Inflammatory Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
  • Bier J; Immunity and Inflammatory Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
  • Reed JH; Immunity and Inflammatory Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
  • Smart JM; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Cole T; Immunity and Inflammatory Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
  • Choo S; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Gray PE; Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Victoria, Australia.
  • Berglund LJ; Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Victoria, Australia.
  • Hsu P; Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Victoria, Australia.
  • Wong M; School of Women's and Children's Health, UNSW Sydney, Sydney, Australia.
  • O'Sullivan M; Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
  • Boztug K; Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
  • Meyts I; Immunopathology Department, Westmead Hospital, Westmead, New South Wales, Australia.
  • Uzel G; Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.
  • Notarangelo LD; Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
  • Brink R; Children's Hospital at Westmead, New South Wales, Australia.
  • Goodnow CC; Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
  • Tangye SG; Children's Hospital at Westmead, New South Wales, Australia.
  • Deenick EK; Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
J Exp Med ; 217(2)2020 02 03.
Article in En | MEDLINE | ID: mdl-31841125
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasma Cells / Autoantibodies / Class I Phosphatidylinositol 3-Kinases / Gain of Function Mutation / Immune Tolerance / Antibody Formation Type of study: Etiology_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Exp Med Year: 2020 Document type: Article Affiliation country: Australia Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasma Cells / Autoantibodies / Class I Phosphatidylinositol 3-Kinases / Gain of Function Mutation / Immune Tolerance / Antibody Formation Type of study: Etiology_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Exp Med Year: 2020 Document type: Article Affiliation country: Australia Country of publication: Estados Unidos