Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice.

Miura, Tomonori; Uehara, Shotaro; Shimizu, Makiko; Murayama, Norie; Utoh, Masahiro; Suemizu, Hiroshi; Yamazaki, Hiroshi

Miura, Tomonori; Uehara, Shotaro; Shimizu, Makiko; Murayama, Norie; Utoh, Masahiro; Suemizu, Hiroshi; Yamazaki, Hiroshi.

Affiliation

Miura T; Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University , Tokyo 194-8543 , Japan.
Uehara S; Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University , Tokyo 194-8543 , Japan.
Shimizu M; Laboratory Animal Research Department , Central Institute for Experimental Animals , Kawasaki 210-0821 , Japan.
Murayama N; Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University , Tokyo 194-8543 , Japan.
Utoh M; Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University , Tokyo 194-8543 , Japan.
Suemizu H; Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University , Tokyo 194-8543 , Japan.
Yamazaki H; Laboratory Animal Research Department , Central Institute for Experimental Animals , Kawasaki 210-0821 , Japan.

Chem Res Toxicol ; 33(2): 634-639, 2020 02 17.

Article in En | MEDLINE | ID: mdl-31854189

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diclofenac / Transplantation Chimera / Hepatocytes / Cytochrome P-450 CYP3A / Cytochrome P-450 CYP2C9 Limits: Animals / Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2020 Document type: Article Affiliation country: Japón

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