Development of an in vitro screening assay for PIP5K1&#945; lipid kinase and identification of potent inhibitors.

Strätker, Katja; Haidar, Samer; Amesty, Ángel; El-Awaad, Ehab; Götz, Claudia; Estévez-Braun, Ana; Jose, Joachim

Development of an in vitro screening assay for PIP5K1α lipid kinase and identification of potent inhibitors.

Strätker, Katja; Haidar, Samer; Amesty, Ángel; El-Awaad, Ehab; Götz, Claudia; Estévez-Braun, Ana; Jose, Joachim.

Affiliation

Strätker K; Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Germany.
Haidar S; Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Germany.
Amesty Á; Faculty of Pharmacy, Damascus University, Syria.
El-Awaad E; Departamento de Química Orgánica, Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Spain.
Götz C; Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Germany.
Estévez-Braun A; Department of Pharmacology, Faculty of Medicine, Assiut University, Egypt.
Jose J; Universität des Saarlandes Medizinische Biochemie und Molekularbiologie Geb, Homburg, Germany.

FEBS J ; 287(14): 3042-3064, 2020 07.

Article in En | MEDLINE | ID: mdl-31876381

Subject(s)
Key words

PIP5K1α; benzoquinone; capillary electrophoresis; lipid kinase; prostate cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Phosphotransferases (Alcohol Group Acceptor) / Protein Kinase Inhibitors / Drug Discovery Type of study: Diagnostic_studies / Screening_studies Limits: Humans / Male Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2020 Document type: Article Affiliation country: Alemania

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