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Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis.
Gomez-Giro, Gemma; Arias-Fuenzalida, Jonathan; Jarazo, Javier; Zeuschner, Dagmar; Ali, Muhammad; Possemis, Nina; Bolognin, Silvia; Halder, Rashi; Jäger, Christian; Kuper, Willemijn F E; van Hasselt, Peter M; Zaehres, Holm; Del Sol, Antonio; van der Putten, Herman; Schöler, Hans R; Schwamborn, Jens C.
Affiliation
  • Gomez-Giro G; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Developmental and Cellular Biology, University of Luxembourg, Avenue du Swing 6, Belvaux, Luxembourg.
  • Arias-Fuenzalida J; Laboratory of Cellular and Developmental Biologie, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse, Münster, Germany.
  • Jarazo J; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Developmental and Cellular Biology, University of Luxembourg, Avenue du Swing 6, Belvaux, Luxembourg.
  • Zeuschner D; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Developmental and Cellular Biology, University of Luxembourg, Avenue du Swing 6, Belvaux, Luxembourg.
  • Ali M; Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse, Münster, Germany.
  • Possemis N; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Computational Biology, University of Luxembourg, Avenue du Swing 6, Belvaux, Luxembourg.
  • Bolognin S; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, the Netherlands.
  • Halder R; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Developmental and Cellular Biology, University of Luxembourg, Avenue du Swing 6, Belvaux, Luxembourg.
  • Jäger C; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Developmental and Cellular Biology, University of Luxembourg, Avenue du Swing 6, Belvaux, Luxembourg.
  • Kuper WFE; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Eco-Systems Biology, University of Luxembourg, Avenue des Hauts Fourneaux 7, Esch-sur-Alzette, Luxembourg.
  • van Hasselt PM; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Enzymology and Metabolism, University of Luxembourg, Avenue du Swing 6, Esch-sur-Alzette, Luxembourg.
  • Zaehres H; Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Del Sol A; Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
  • van der Putten H; Laboratory of Cellular and Developmental Biologie, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse, Münster, Germany.
  • Schöler HR; Ruhr-University Bochum, Medical Faculty, Department of Anatomy and Molecular Embryology, Bochum, Germany.
  • Schwamborn JC; Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Computational Biology, University of Luxembourg, Avenue du Swing 6, Belvaux, Luxembourg.
Acta Neuropathol Commun ; 7(1): 222, 2019 12 30.
Article in En | MEDLINE | ID: mdl-31888773

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Membrane Glycoproteins / Cerebral Cortex / Molecular Chaperones / Neuronal Ceroid-Lipofuscinoses / Neurons Type of study: Prognostic_studies Limits: Humans Language: En Journal: Acta Neuropathol Commun Year: 2019 Document type: Article Affiliation country: Luxemburgo

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Membrane Glycoproteins / Cerebral Cortex / Molecular Chaperones / Neuronal Ceroid-Lipofuscinoses / Neurons Type of study: Prognostic_studies Limits: Humans Language: En Journal: Acta Neuropathol Commun Year: 2019 Document type: Article Affiliation country: Luxemburgo