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Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection.
Lal, Kerri G; Kim, Dohoon; Costanzo, Margaret C; Creegan, Matthew; Leeansyah, Edwin; Dias, Joana; Paquin-Proulx, Dominic; Eller, Leigh Anne; Schuetz, Alexandra; Phuang-Ngern, Yuwadee; Krebs, Shelly J; Slike, Bonnie M; Kibuuka, Hannah; Maganga, Lucas; Nitayaphan, Sorachai; Kosgei, Josphat; Sacdalan, Carlo; Ananworanich, Jintanat; Bolton, Diane L; Michael, Nelson L; Shacklett, Barbara L; Robb, Merlin L; Eller, Michael A; Sandberg, Johan K.
Affiliation
  • Lal KG; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Kim D; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Costanzo MC; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Creegan M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Leeansyah E; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Dias J; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Paquin-Proulx D; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Eller LA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Schuetz A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Phuang-Ngern Y; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Krebs SJ; Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Slike BM; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Kibuuka H; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Maganga L; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Nitayaphan S; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Kosgei J; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Sacdalan C; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Ananworanich J; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Bolton DL; Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Michael NL; Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Shacklett BL; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Robb ML; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Eller MA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Sandberg JK; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Nat Commun ; 11(1): 272, 2020 01 14.
Article in En | MEDLINE | ID: mdl-31937782
ABSTRACT
Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viremia / HIV Infections / Mucosal-Associated Invariant T Cells Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viremia / HIV Infections / Mucosal-Associated Invariant T Cells Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Estados Unidos