Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.
Nat Commun
; 11(1): 597, 2020 01 30.
Article
in En
| MEDLINE
| ID: mdl-32001714
ABSTRACT
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR] 0.51, 95% confidence interval [CI] 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR 0.66, 95% CI 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Colorectal Neoplasms
/
Exercise
/
Genetic Predisposition to Disease
/
Mendelian Randomization Analysis
Type of study:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Nat Commun
Journal subject:
BIOLOGIA
/
CIENCIA
Year:
2020
Document type:
Article
Affiliation country:
Francia