Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.
Biochim Biophys Acta Mol Basis Dis
; 1866(6): 165716, 2020 06 01.
Article
in En
| MEDLINE
| ID: mdl-32061776
ABSTRACT
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of ironsulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfur
/
Thiosulfate Sulfurtransferase
/
Metabolic Diseases
/
Antioxidants
Limits:
Humans
Language:
En
Journal:
Biochim Biophys Acta Mol Basis Dis
Year:
2020
Document type:
Article
Affiliation country:
Países Bajos