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Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.
Kruithof, Paul D; Lunev, Sergey; Aguilar Lozano, Sheila P; de Assis Batista, Fernando; Al-Dahmani, Zayana M; Joles, Jaap A; Dolga, Amalia M; Groves, Matthew R; van Goor, Harry.
Affiliation
  • Kruithof PD; Univeristy of Groningen, Department of Pharmacy and Drug Design, the Netherlands.
  • Lunev S; Univeristy of Groningen, Department of Pharmacy and Drug Design, the Netherlands.
  • Aguilar Lozano SP; Univeristy of Groningen, Department of Pharmacy and Drug Design, the Netherlands.
  • de Assis Batista F; Univeristy of Groningen, Department of Pharmacy and Drug Design, the Netherlands.
  • Al-Dahmani ZM; Univeristy of Groningen, Department of Pharmacy and Drug Design, the Netherlands.
  • Joles JA; University Medical Center Utrecht, Department of Nephrology and Hypertension, the Netherlands.
  • Dolga AM; University of Groningen, Department of Pharmacy, Molecular Pharmacology, the Netherlands.
  • Groves MR; Univeristy of Groningen, Department of Pharmacy and Drug Design, the Netherlands.
  • van Goor H; University Medical Center Groningen, Department of Pathology and Medical Biology the Netherlands. Electronic address: h.van.goor@umcg.nl.
Biochim Biophys Acta Mol Basis Dis ; 1866(6): 165716, 2020 06 01.
Article in En | MEDLINE | ID: mdl-32061776
ABSTRACT
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron­sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfur / Thiosulfate Sulfurtransferase / Metabolic Diseases / Antioxidants Limits: Humans Language: En Journal: Biochim Biophys Acta Mol Basis Dis Year: 2020 Document type: Article Affiliation country: Países Bajos
Fulltext
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Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfur / Thiosulfate Sulfurtransferase / Metabolic Diseases / Antioxidants Limits: Humans Language: En Journal: Biochim Biophys Acta Mol Basis Dis Year: 2020 Document type: Article Affiliation country: Países Bajos