Intact charge variant analysis of ziv-aflibercept by cationic exchange liquid chromatography as a proof of concept: Comparison between volatile and non-volatile salts in the mobile phase.

Pérez-Robles, Raquel; Cuadros-Rodríguez, Luis; Salmerón-García, Antonio; Cabeza-Barrera, José; Navas, Natalia

Pérez-Robles, Raquel; Cuadros-Rodríguez, Luis; Salmerón-García, Antonio; Cabeza-Barrera, José; Navas, Natalia.

Affiliation

Pérez-Robles R; Department of Analytical Chemistry/Biohealth Research Institute (ibs.GRANADA), University of Granada, E-18071 Granada, Spain.
Cuadros-Rodríguez L; Department of Analytical Chemistry/Biohealth Research Institute (ibs.GRANADA), University of Granada, E-18071 Granada, Spain.
Salmerón-García A; Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, (ibs.GRANADA), 18016 Granada, Spain.
Cabeza-Barrera J; Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, (ibs.GRANADA), 18016 Granada, Spain.
Navas N; Department of Analytical Chemistry/Biohealth Research Institute (ibs.GRANADA), University of Granada, E-18071 Granada, Spain. Electronic address: natalia@ugr.es.

J Pharm Biomed Anal ; 185: 113233, 2020 Jun 05.

Article in En | MEDLINE | ID: mdl-32169790

Subject(s)
Key words

Aflibercept; Biodrugs analysis; Fusion protein; Ion exchange chromatography; Isoforms; Stress study

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Chemistry, Pharmaceutical / Receptors, Vascular Endothelial Growth Factor Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Pharm Biomed Anal Year: 2020 Document type: Article Affiliation country: España Country of publication: Reino Unido

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