Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale.
Int J Cardiol Heart Vasc
; 27: 100496, 2020 Apr.
Article
in En
| MEDLINE
| ID: mdl-32181323
ABSTRACT
BACKGROUND:
In the era of High-sensitive troponin (hs-Tn), up to 50% of patients with a mild increase of hs-Tn will finally have a normal invasive coronary angiogram. Fractional Flow Reserve (FFR) derived from coronary computed tomographic angiography (FFR-CT) has never been used as a non-invasive tool for the diagnosis of coronary artery disease in patients with high-risk acute coronary syndrome without ST segment elevation (NSTE-ACS).AIMS:
The study aims to determine the role of coronary CT angiography and FFR-CT in the setting of high-risk NSTE-ACS.METHODOLOGY:
We will conduct a prospective trial, enrolling 250 patients admitted with high-risk NSTE-ACS who will rapidly undergo a coronary CT angiography and then a coronary angiography with FFR measurements. Results of coronary CT, FFR-CT and coronary angiography (± FFR) will be compared. POTENTIALSIGNIFICANCE:
In conclusion, non-invasive identification of patients with high-risk NSTE-ACS who could avoid coronary angiography would reduce procedure related risks and medical costs.
ACS, Acute coronary syndrome; AE, Adverse Event; Acute coronary syndrome; CMRI, Cardiac Magnetic resonance imaging; CT, Computed tomography; Coronary computed tomography; ECG, Electrocardiogram; ED, Emergency department; FFR, Fractional Flow Reserve; FFR-CT; FFR-CT, FFR derived from coronary CT; Fractional Flow Reserve; Hs-Tn, High-sensitive troponins; MACE, Major adverse cardiac events; MI, Myocardial infraction; NSTE-ACS, Acute coronary syndromes without ST-segment elevation; NSTEMI, Non-ST-elevation myocardial infarction; PCI, Percutaneous Coronary Intervention; STEMI, ST-elevation myocardial infarction; URL, Upper Range Limit
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Etiology_studies
/
Risk_factors_studies
Language:
En
Journal:
Int J Cardiol Heart Vasc
Year:
2020
Document type:
Article
Affiliation country:
Suiza