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Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.
Popova, Gergana; Ladds, Marcus J G W; Johansson, Lars; Saleh, Aljona; Larsson, Johanna; Sandberg, Lars; Sahlberg, Sara Häggblad; Qian, Weixing; Gullberg, Hjalmar; Garg, Neeraj; Gustavsson, Anna-Lena; Haraldsson, Martin; Lane, David; Yngve, Ulrika; Lain, Sonia.
Affiliation
  • Popova G; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Stockholm, Sweden.
  • Ladds MJGW; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Stockholm, Sweden.
  • Johansson L; SciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Tomtebodavägen 23, SE-171 21 Solna, Stockholm, Sweden.
  • Saleh A; Chemical Biology Consortium Sweden, SciLifeLab, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 21 Stockholm, Sweden.
  • Larsson J; SciLifeLab, Drug Discovery and Development Platform, ADME of Therapeutics Facility, Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden.
  • Sandberg L; SciLifeLab, Drug Discovery and Development Platform, Department of Medicinal Chemistry, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.
  • Sahlberg SH; SciLifeLab, Drug Discovery and Development Platform, Department of Medicinal Chemistry, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.
  • Qian W; SciLifeLab, Drug Discovery and Development Platform, Department of Organic Chemistry, Stockholm University, Box 1030, SE-171 21 Solna, Stockholm, Sweden.
  • Gullberg H; SciLifeLab, Drug Discovery and Development Platform, Department of Biochemistry and Biophysics, Stockholm University, SE-171 21 Solna, Stockholm, Sweden.
  • Garg N; Chemical Biology Consortium Sweden, Laboratories for Chemical Biology Umeå, Umeå University, SE-901 87 Umeå, Sweden.
  • Gustavsson AL; SciLifeLab, Drug Discovery and Development Platform, Department of Biochemistry and Biophysics, Stockholm University, SE-171 21 Solna, Stockholm, Sweden.
  • Haraldsson M; SciLifeLab, Drug Discovery and Development Platform, Department of Medicinal Chemistry, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.
  • Lane D; Chemical Biology Consortium Sweden, SciLifeLab, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 21 Stockholm, Sweden.
  • Yngve U; Chemical Biology Consortium Sweden, SciLifeLab, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 21 Stockholm, Sweden.
  • Lain S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Stockholm, Sweden.
J Med Chem ; 63(8): 3915-3934, 2020 04 23.
Article in En | MEDLINE | ID: mdl-32212728
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases Acting on CH-CH Group Donors / Enzyme Inhibitors / Indazoles Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Suecia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases Acting on CH-CH Group Donors / Enzyme Inhibitors / Indazoles Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Suecia