Histamine-2 receptor antagonists (H2RA) may negatively impact ADL assessment in patients on a convalescent rehabilitation ward.
Pharmazie
; 75(2): 82-89, 2020 03 20.
Article
in En
| MEDLINE
| ID: mdl-32213239
ABSTRACT
Background/aim:
In the convalescent rehabilitation ward, many elderly patients undergo rehabilitation. Histamine-2 receptor antagonists (H2RA), which is a one of the acid secretion inhibitors, is frequently prescribed for the patients as a peptic ulcer prevention measure. At present, H2RA are reported as being associated with factors that reduce cognitive function. However, little is known about the relationship H2RA and rehabilitation outcome. Therefore, this study examined the relationship between H2RA use and Functional Independence Measure (FIM) gain, which determines rehabilitation outcomes for patients admitted to the convalescent rehabilitation ward. Patients andmethods:
We retrospectively investigated FIM gain on discharge by both the administration group (H2RA (+)) (n = 118) and non-administration group (H2RA (-)) (n = 118).Results:
The FIM gain scores of Motor FIM total, Cognition FIM total, and Total FIM were significantly lower in H2RA (+) than in H2RA (-) (Motor FIM total 8.0 [4.0-16.0] [Inter-Quartile Range] vs. 12.0 [5.0-19.2], p =0.0217, Cognition FIM total 3.0 [1.0-6.0] vs. 5.0 [2.0-7.0], p =0.0120, Total FIM 11.5 [4.8-20.2] vs. 17.0 [8.0-27.0], p =0.0089).Conclusion:
The administration of H2RA to elderly patients undergoing rehabilitation may prevent cognitive function maintenance or recovery by rehabilitation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Activities of Daily Living
/
Cognition
/
Recovery of Function
/
Histamine H2 Antagonists
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Pharmazie
Journal subject:
FARMACIA
Year:
2020
Document type:
Article