Effectiveness of Adjunctive Analgesics in Head and Neck Cancer Patients Receiving Curative (Chemo-) Radiotherapy: A Systematic Review.
Pain Med
; 22(1): 152-164, 2021 02 04.
Article
in En
| MEDLINE
| ID: mdl-32219435
ABSTRACT
OBJECTIVE:
Our aim was to give an overview of the effectiveness of adjunctive analgesics in head and neck cancer (HNC) patients receiving (chemo-) radiotherapy.DESIGN:
Systematic review.INTERVENTIONS:
This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched for studies concerning "head neck cancer," "adjunctive analgesics," "pain," and "radiotherapy." OUTCOMEMEASURES:
Pain outcome, adverse events, and toxicity and other reported outcomes, for example, mucositis, quality of life, depression, etc.RESULTS:
Nine studies were included in our synthesis. Most studies were of low quality and had a high risk of bias on several domains of the Cochrane Collaboration tool. Only two studies comprised high-quality randomized controlled trials in which pregabalin and a doxepin rinse showed their effectiveness for the treatment of neuropathic pain and pain from oral mucositis, respectively, in HNC patients receiving (chemo-) radiotherapy.CONCLUSIONS:
More high-quality trials are necessary to provide clear evidence on the effectiveness of adjunctive analgesics in the treatment of HNC (chemo-) radiation-induced pain.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomatitis
/
Head and Neck Neoplasms
Type of study:
Clinical_trials
/
Guideline
/
Systematic_reviews
Aspects:
Patient_preference
Limits:
Humans
Language:
En
Journal:
Pain Med
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
Bélgica