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Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
Byrne, Matthew J; Nasir, Nazia; Basmadjian, Christine; Bhatia, Chitra; Cunnison, Rory F; Carr, Katherine H; Mas-Droux, Corine; Yeoh, Sharon; Cano, Céline; Bayliss, Richard.
Affiliation
  • Byrne MJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K.
  • Nasir N; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K.
  • Basmadjian C; Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, U.K.
  • Bhatia C; Department of Molecular and Cell Biology, University of Leicester, Leicester, U.K.
  • Cunnison RF; Department of Molecular and Cell Biology, University of Leicester, Leicester, U.K.
  • Carr KH; Department of Molecular and Cell Biology, University of Leicester, Leicester, U.K.
  • Mas-Droux C; Section of Structural Biology, The Institute of Cancer Research, London, U.K.
  • Yeoh S; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K.
  • Cano C; Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, U.K.
  • Bayliss R; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K.
Biochem J ; 477(8): 1525-1539, 2020 04 30.
Article in En | MEDLINE | ID: mdl-32242624
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / NIMA-Related Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem J Year: 2020 Document type: Article Affiliation country: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / NIMA-Related Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem J Year: 2020 Document type: Article Affiliation country: Reino Unido