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Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases.
Jochems, Angela C C; Blair, Gordon W; Stringer, Michael S; Thrippleton, Michael J; Clancy, Una; Chappell, Francesca M; Brown, Rosalind; Jaime Garcia, Daniela; Hamilton, Olivia K L; Morgan, Alasdair G; Marshall, Ian; Hetherington, Kirstie; Wiseman, Stewart; MacGillivray, Tom; Valdés-Hernández, Maria C; Doubal, Fergus N; Wardlaw, Joanna M.
Affiliation
  • Jochems ACC; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Blair GW; UK Dementia Research Institute (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., D.J.G., O.K.L.H., S.W., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Stringer MS; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Thrippleton MJ; UK Dementia Research Institute (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., D.J.G., O.K.L.H., S.W., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Clancy U; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Chappell FM; UK Dementia Research Institute (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., D.J.G., O.K.L.H., S.W., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Brown R; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Jaime Garcia D; UK Dementia Research Institute (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., D.J.G., O.K.L.H., S.W., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Hamilton OKL; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Morgan AG; UK Dementia Research Institute (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., D.J.G., O.K.L.H., S.W., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Marshall I; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Hetherington K; UK Dementia Research Institute (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., D.J.G., O.K.L.H., S.W., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Wiseman S; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • MacGillivray T; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Valdés-Hernández MC; UK Dementia Research Institute (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., D.J.G., O.K.L.H., S.W., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Doubal FN; From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
  • Wardlaw JM; UK Dementia Research Institute (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., D.J.G., O.K.L.H., S.W., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.
Stroke ; 51(5): 1503-1506, 2020 05.
Article in En | MEDLINE | ID: mdl-32264759
ABSTRACT
Background and Purpose- Perivascular spaces (PVS) around venules may help drain interstitial fluid from the brain. We examined relationships between suspected venules and PVS visible on brain magnetic resonance imaging. Methods- We developed a visual venular quantification method to examine the spatial relationship between venules and PVS. We recruited patients with lacunar stroke or minor nondisabling ischemic stroke and performed brain magnetic resonance imaging and retinal imaging. We quantified venules on gradient echo or susceptibility-weighted imaging and PVS on T2-weighted magnetic resonance imaging in the centrum semiovale and then determined overlap between venules and PVS. We assessed associations between venular count and patient demographic characteristics, vascular risk factors, small vessel disease features, retinal vessels, and venous sinus pulsatility. Results- Among 67 patients (69% men, 69.0±9.8 years), only 4.6% (range, 0%-18%) of venules overlapped with PVS. Total venular count increased with total centrum semiovale PVS count in 55 patients after accounting for venule-PVS overlap (ß=0.468 [95% CI, 0.187-0.750]) and transverse sinus pulsatility (ß=0.547 [95% CI, 0.309-0.786]) and adjusting for age, sex, and systolic blood pressure. Conclusions- Despite increases in both visible PVS and suspected venules, we found minimal spatial overlap between them in patients with sporadic small vessel disease, suggesting that most magnetic resonance imaging-visible centrum semiovale PVS are periarteriolar rather than perivenular.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Venules / Brain / Cerebral Small Vessel Diseases / Glymphatic System Type of study: Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Stroke Year: 2020 Document type: Article Affiliation country: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Venules / Brain / Cerebral Small Vessel Diseases / Glymphatic System Type of study: Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Stroke Year: 2020 Document type: Article Affiliation country: Reino Unido