Your browser doesn't support javascript.
loading
The Zn(S-pr-thiosal)2 complex attenuates murine breast cancer growth by inducing apoptosis and G1/S cell cycle arrest.
Benazic, Sasa; Silconi, Zana Besser; Jevtovic, Andra; Jurisevic, Milena; Milovanovic, Jelena; Mijajlovic, Marina; Nikolic, Milos; Kanjevac, Tatjana; Potocnák, Ivan; Samolová, Erika; Ratkovic, Zoran R; Radic, Gordana; Milovanovic, Marija; Pantic, Jelena; Arsenijevic, Nebojsa; Radosavljevic, Gordana D.
Affiliation
  • Benazic S; Department of Transfusiology, Pula General Hospital, Pula, 52100, Croatia.
  • Silconi ZB; Department of Cytology, Pula General Hospital, Pula, 52100, Croatia.
  • Jevtovic A; Center for Molecular Medicine & Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
  • Jurisevic M; Department of Otorhinolaryngology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia.
  • Milovanovic J; Center for Molecular Medicine & Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
  • Mijajlovic M; Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia.
  • Nikolic M; Center for Molecular Medicine & Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
  • Kanjevac T; Department of Histology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia.
  • Potocnák I; Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia.
  • Samolová E; Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia.
  • Ratkovic ZR; Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia.
  • Radic G; Institute of Chemistry, Faculty of Science, P.J. Safárik University in Kosice, Kosice, 34000, Slovakia.
  • Milovanovic M; Institute of Chemistry, Faculty of Science, P.J. Safárik University in Kosice, Kosice, 34000, Slovakia.
  • Pantic J; Department of Chemistry, Faculty of Science, University of Kragujevac, Kragujevac, 34000, Serbia.
  • Arsenijevic N; Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia.
  • Radosavljevic GD; Center for Molecular Medicine & Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
Future Med Chem ; 12(10): 897-914, 2020 05.
Article in En | MEDLINE | ID: mdl-32267176
ABSTRACT

Aim:

We investigated the antitumor effects of zinc(II) complex with S-propyl thiosalicylic acid [Zn(S-pr-thiosal)2] in 4T1 murine breast cancer model.

Results:

 The Zn(S-pr-thiosal)2 complex reduced primary tumor growth in vivo and induced tumor cell apoptosis. The Zn(S-pr-thiosal)2 complex disrupted the balance between pro- and antiapoptotic Bcl-2 family members in 4T1 cells and induced G1/S cell cycle arrest. The Zn(S-pr-thiosal)2 complex increased the percentage of p16, p21 and p27 positive 4T1 cells. There was a significantly decrease in expression of STAT3 and its targets c-Myc and cyclin D3 in 4T1 cells treated with the Zn(S-pr-thiosal)2 complex thus contributing to G1/S cell cycle arrest and/or apoptosis.

Conclusion:

Our data suggest that the Zn(S-pr-thiosal)2 complex restricted tumor growth through induction of mitochondrial-driven apoptosis and suppression of cell cycle progression.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfhydryl Compounds / Zinc / Breast Neoplasms / Apoptosis / Coordination Complexes / Antineoplastic Agents Limits: Animals Language: En Journal: Future Med Chem Year: 2020 Document type: Article Affiliation country: Croacia
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfhydryl Compounds / Zinc / Breast Neoplasms / Apoptosis / Coordination Complexes / Antineoplastic Agents Limits: Animals Language: En Journal: Future Med Chem Year: 2020 Document type: Article Affiliation country: Croacia