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Discovery of orally active indirubin-3'-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemia.
Jeong, Pyeonghwa; Moon, Yeongyu; Lee, Je-Heon; Lee, So-Deok; Park, Jiyeon; Lee, Jungeun; Kim, Jiheon; Lee, Hyo Jeong; Kim, Na Yoon; Choi, Jungil; Heo, Jeong Doo; Shin, Ji Eun; Park, Hyun Woo; Kim, Yoon-Gyoon; Han, Sun-Young; Kim, Yong-Chul.
Affiliation
  • Jeong P; Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Moon Y; Bioenvironmental Science & Toxicology Division, Gyeongnam Branch Institute, Korea Institute of Toxicology, Jinju, Gyeongsangnam-do, 52834, Republic of Korea.
  • Lee JH; School of Life Sciences and Center for AI-applied High Efficiency Drug Discovery, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Lee SD; School of Life Sciences and Center for AI-applied High Efficiency Drug Discovery, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Park J; School of Life Sciences and Center for AI-applied High Efficiency Drug Discovery, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Lee J; School of Life Sciences and Center for AI-applied High Efficiency Drug Discovery, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Kim J; School of Life Sciences and Center for AI-applied High Efficiency Drug Discovery, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Lee HJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do, 52828, Republic of Korea.
  • Kim NY; College of Pharmacy, Dankook University, Cheonan, 330-714, Republic of Korea.
  • Choi J; Bioenvironmental Science & Toxicology Division, Gyeongnam Branch Institute, Korea Institute of Toxicology, Jinju, Gyeongsangnam-do, 52834, Republic of Korea.
  • Heo JD; Bioenvironmental Science & Toxicology Division, Gyeongnam Branch Institute, Korea Institute of Toxicology, Jinju, Gyeongsangnam-do, 52834, Republic of Korea.
  • Shin JE; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
  • Park HW; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
  • Kim YG; College of Pharmacy, Dankook University, Cheonan, 330-714, Republic of Korea.
  • Han SY; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do, 52828, Republic of Korea. Electronic address: syhan@gnu.ac.kr.
  • Kim YC; Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea; School of Life Sciences and Center for AI-applied High Efficiency Drug Discovery, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. Electronic address: yongchul@gist.ac
Eur J Med Chem ; 195: 112205, 2020 Jun 01.
Article in En | MEDLINE | ID: mdl-32272419
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Drug Design / Leukemia, Myeloid, Acute / Fms-Like Tyrosine Kinase 3 / Indoles Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2020 Document type: Article Country of publication: Francia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Drug Design / Leukemia, Myeloid, Acute / Fms-Like Tyrosine Kinase 3 / Indoles Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2020 Document type: Article Country of publication: Francia