Novel delivery based anionic linear globular dendrimerg2-zidovudine nano-conjugate significantly decreased retroviral activity.
Pak J Pharm Sci
; 33(2): 705-714, 2020 Mar.
Article
in En
| MEDLINE
| ID: mdl-32276917
ABSTRACT
Human diseases like viral organisms for example, hepatitis, HIV and etc., attack the health and caused large mortality in populations by many years. So finding novel delivery vehicles based antiviral drugs employing nano-materials is of high universal interest. In current approach a very biocompatible biodegradable nano-biopolymer anionic linear globular dendrimer second generation G2 was elaborately conjugated to a well-known anti-HIV drug Azidovudine and thereafter was characterized by different analytical techniques like AFM, Zeta sizer, 1HNMR, FTIR and LC-Mass spectroscopy. Then, Anionic Linear Globular DendrimerG2-Zidovudine Nano-Conjugate was assessed on human normal cells (toxicity assay by XTT test) and also HIV cell model and the results showed that Anionic Linear Globular DendrimerG2-Zidovudine Nano-Conjugate Significantly Decreased Retroviral Activity without any human cell toxicity respectively. Based on current experimental data such nano-compositions is proposed for further in vivo anti-HIV assays as well.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Zidovudine
/
Cell Survival
/
Drug Delivery Systems
/
Anti-Retroviral Agents
/
Dendrimers
/
Nanoconjugates
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Pak J Pharm Sci
Journal subject:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Year:
2020
Document type:
Article
Affiliation country:
Irán
Publication country:
PAKISTAN
/
PAQUISTÃO
/
PK