Predictive factors of pathological response to neoadjuvant chemotherapy in patients with breast cancer.
J BUON
; 25(1): 168-175, 2020.
Article
in En
| MEDLINE
| ID: mdl-32277628
ABSTRACT
PURPOSE:
To identify predictive factors connected with pathologic response in patients with breast cancer (BC) having received neoadjuvant chemotherapy (NACT).METHODS:
49 patients with BC were investigated before and after treatment in this prospective research. Different chemotherapy regimes were administered. The Miller-Payne scoring system was used to assess the tumour response. The nuclear proliferation markers Ki67 and the expression of topoisomerase IIα (Topo IIα) were evaluated.RESULTS:
Six patients (12.2 %) achieved pathological complete response (pCR). Noticeable decrease of tumor cellularity was detected in all BC subtypes and pCR in the triple-negative BC (TNBC) group (p=0.007) was observed. Poorly differentiated tumors could be considered as predictive factors of pCR (p=0.07). Ki67 appeared to be a predictive marker of achieving pCR (p<0.001) with a threshold of 28% (AUC=0.89, 95% CI 0.75-0.96). The additional factor of reaching pCR was operable BC (p=0.04). The expression level of Topo IIα (p=0.50) and using different regimens of NACT (p=0.97) did not influence pCR achievement.CONCLUSION:
To sum it up, poorly differentiated carcinomas with high cellularity in the primary tumor, TNBC, Ki 67 with a threshold above 28% and operable BC can be considered as early predictors of reaching pCR.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Genetic Testing
/
Neoadjuvant Therapy
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
J BUON
Journal subject:
NEOPLASIAS
Year:
2020
Document type:
Article
Affiliation country:
Ucrania