N-terminal pro-brain natriuretic peptide used for screening hemodynamically significant patent ductus arteriosus in very low birth weight infants: How and when?
Clin Hemorheol Microcirc
; 75(3): 335-347, 2020.
Article
in En
| MEDLINE
| ID: mdl-32280084
ABSTRACT
BACKGROUND:
N-terminal pro-B-type natriuretic peptide (NTproBNP) appears to be a useful tool for diagnosing hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. However, a consensus for its application has not been reached.OBJECTIVE:
The present study aims to evaluate the role of NTproBNP in predicting hsPDA in preterm infants, and explore the optimal cutoff value and testing-time.METHODS:
A prospective blind study of 120 preterm infants with birth weights ofâ<â1,500âg was conducted at the NICU of Peking University Shenzhen Hospital. Blood samples were successively collected on the first three days after birth for NTproBNP analysis. Echocardiographies were performed on day three of life to confirm the status of the ductus arteriosus. A receiver operating characteristic curve (ROC) analysis was performed to determine the ability of NTproBNP to recognize hsPDA.RESULTS:
NTproBNP was significantly higher in infants with hsPDA, than in infants in the control group, on both day two (Pâ<â0.001) and day three (Pâ<â0.001). On day two, a NTproBNP cutoff value of 3,689.0 pmol/L offered an optimal predictive value for hsPDA, while on day three, the optimal cut-off value for hsPDA was 2,331.5 pmol/L. The investigators proposes day three of life (48-72 hours) as the optimal testing time.CONCLUSION:
The NTproBNP biomarker during the early neonatal period can be a useful tool for screening and assessing hsPDA in premature infants, especially on day three of life.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Infant, Premature
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Biomarkers
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Infant, Very Low Birth Weight
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Natriuretic Peptide, Brain
/
Ductus Arteriosus, Patent
/
Hemodynamics
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
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Infant
/
Male
/
Newborn
Language:
En
Journal:
Clin Hemorheol Microcirc
Journal subject:
ANGIOLOGIA
/
HEMATOLOGIA
Year:
2020
Document type:
Article
Affiliation country:
China