The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats.
BMC Neurosci
; 21(1): 15, 2020 04 16.
Article
in En
| MEDLINE
| ID: mdl-32299361
BACKGROUND: Vasomotor regulation of dermal blood vessels, which are critical in the function of the skin in thermoregulatory control, involves both neural and non-neural mechanisms. Whereas the role of sympathetic nerves in regulating vasomotor activities is comprehensively studied and well recognized, that of sensory nerves is underappreciated. Studies in rodents have shown that severance of the sciatic nerve leads to vasodilatation in the foot, but whether sympathetic or sensory nerve fibers or both are responsible for the neurogenic vasodilatation remains unknown. RESULTS: In adult Sprague-Dawley rats, vasodilatation after transection of the sciatic nerve gradually diminished to normal within 3-4 days. The neurotmesis-induced neurogenic vasodilatation was not detectable when the sciatic nerve was chronically deafferentated by selective resection of the dorsal root ganglia (DRGs) that supply the nerve. Specific activation of C-afferents by intra-neural injection of capsaicin resulted in neurogenic vasodilatation to a magnitude comparable to that by neurotmesis, and transection of the sciatic nerve pre-injected with capsaicin did not induce further vasodilatation. CONCLUSIONS: Our results collectively indicate that vasodilatation after traumatic nerve injury in rats is predominantly mediated by C-fiber afferents.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sciatic Nerve
/
Skin
/
Vasodilation
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Capsaicin
/
Sciatic Neuropathy
Limits:
Animals
Language:
En
Journal:
BMC Neurosci
Journal subject:
NEUROLOGIA
Year:
2020
Document type:
Article
Affiliation country:
China
Country of publication:
Reino Unido