Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers.
J Neurol
; 267(8): 2296-2300, 2020 Aug.
Article
in En
| MEDLINE
| ID: mdl-32318850
ABSTRACT
Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions of putaminal 18F-DOPA uptake. Three of them had significantly raised nigral 11C-PK11195 binding bilaterally. These findings indicate that nigrostriatal dysfunction and neuroinflammation occur in LRRK2-NMCs. Studies in larger cohorts with appropriate follow-up are needed to elucidate the significance of neuroinflammation in the premotor phase of LRRK2-PD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Dopamine
Limits:
Humans
Language:
En
Journal:
J Neurol
Year:
2020
Document type:
Article
Affiliation country:
Dinamarca