Circulating miR-3135b and miR-107 are potential biomarkers for severe hypertension.
J Hum Hypertens
; 35(4): 343-350, 2021 04.
Article
in En
| MEDLINE
| ID: mdl-32327699
ABSTRACT
Hypertension is a disease relating to multiple etiological factors. However, the molecular mechanisms of severe hypertension remain unclear. Whole-body circulatory dysregulation has been found to contribute to hypertension, documenting that circulating molecules are focused as pathological molecules implicated in hypertension. Circulating microRNAs (miRNAs) have been identified as important molecular biomarkers for hypertension. We screened and analyzed miRNAs differentially expressed in plasma in patients with severe hypertension and healthy controls using microarray profiling (six patients and six healthy controls for screening) and RT-qPCR (33 patients and 33 healthy controls for validation). We identified that miR-3135b and miR-107 are the differentially expressed miRNAs between severe hypertension and healthy controls, and the target genes independently regulated by the two miRNAs are remarkably different. MiR-3135b and miR-107 are potential biomarkers for severe hypertension.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
MicroRNAs
/
Circulating MicroRNA
/
Hypertension
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Hum Hypertens
Journal subject:
ANGIOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
China