[Pathophysiology of autoinflammatory dermatoses]. / Pathophysiologie der autoinflammatorischen Dermatosen.
Hautarzt
; 71(5): 333-341, 2020 May.
Article
in De
| MEDLINE
| ID: mdl-32333042
ABSTRACT
Autoinflammation leads to inflammation that mostly occurs without any clinically obvious reason. It can be so severe that organ damage with relevant tissue damage occurs. Inflammasomes are the drivers of autoinflammation. Although IL1 beta and the inflammasomes as its critical regulators are very important in autoinflammation, not all patients respond to inhibition of this signalling pathway. Several autoinflammatory diseases were associated with mutations in proteasome-immunoproteasome components. Autoinflammatory diseases caused by highly relevant genetic variants are mostly hereditary. Usually in childhood but not always. The coming years will show whether inflammatory dermatoses will be increasingly treated with suppression of the innate immune system in addition to inhibition of adaptive immunity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Diseases
/
Dermatitis
/
Hereditary Autoinflammatory Diseases
Limits:
Child
/
Humans
Language:
De
Journal:
Hautarzt
Year:
2020
Document type:
Article