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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
Schulze, Volker K; Klar, Ulrich; Kosemund, Dirk; Wengner, Antje M; Siemeister, Gerhard; Stöckigt, Detlef; Neuhaus, Roland; Lienau, Philip; Bader, Benjamin; Prechtl, Stefan; Holton, Simon J; Briem, Hans; Marquardt, Tobias; Schirok, Hartmut; Jautelat, Rolf; Bohlmann, Rolf; Nguyen, Duy; Fernández-Montalván, Amaury E; Bömer, Ulf; Eberspaecher, Uwe; Brüning, Michael; Döhr, Olaf; Raschke, Marian; Kreft, Bertolt; Mumberg, Dominik; Ziegelbauer, Karl; Brands, Michael; von Nussbaum, Franz; Koppitz, Marcus.
Affiliation
  • Schulze VK; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Klar U; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Kosemund D; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Wengner AM; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Siemeister G; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Stöckigt D; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Neuhaus R; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Lienau P; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Bader B; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Prechtl S; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Holton SJ; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Briem H; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Marquardt T; Research & Development, Pharmaceuticals, Bayer AG, 42113 Wuppertal, Germany.
  • Schirok H; Research & Development, Pharmaceuticals, Bayer AG, 42113 Wuppertal, Germany.
  • Jautelat R; Research & Development, Pharmaceuticals, Bayer AG, 42113 Wuppertal, Germany.
  • Bohlmann R; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Nguyen D; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Fernández-Montalván AE; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Bömer U; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Eberspaecher U; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Brüning M; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Döhr O; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Raschke M; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Kreft B; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Mumberg D; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Ziegelbauer K; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Brands M; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • von Nussbaum F; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
  • Koppitz M; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.
J Med Chem ; 63(15): 8025-8042, 2020 08 13.
Article in En | MEDLINE | ID: mdl-32338514
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Drug Delivery Systems / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Drug Discovery / M Phase Cell Cycle Checkpoints / Spindle Apparatus / Antineoplastic Agents Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Alemania
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Drug Delivery Systems / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Drug Discovery / M Phase Cell Cycle Checkpoints / Spindle Apparatus / Antineoplastic Agents Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Alemania