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Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA.
Sales, Mia Jade; Sakoulas, George; Szubin, Richard; Palsson, Bernhard; Arias, Cesar; Singh, Kavindra V; Murray, Barbara E; Monk, Jonathan M.
Affiliation
  • Sales MJ; Bioengineering Department, University of California San Diego, La Jolla, California, USA.
  • Sakoulas G; Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.
  • Szubin R; Bioengineering Department, University of California San Diego, La Jolla, California, USA.
  • Palsson B; Bioengineering Department, University of California San Diego, La Jolla, California, USA.
  • Arias C; Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.
  • Singh KV; Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
  • Murray BE; Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
  • Monk JM; Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
Microbiol Resour Announc ; 9(18)2020 Apr 30.
Article in En | MEDLINE | ID: mdl-32354985
ABSTRACT
Staphylococcus aureus strain TX0117 is a methicillin-susceptible bacterium with type A beta-lactamase exhibiting a high cefazolin inoculum effect. TX0117 was cured of blaZ, yielding TX0117c with increased antimicrobial peptide resistance. The sequencing and genome assembly of TX0117 elucidate six mutations between TX0117 and TX0117c, including relA truncation and mnA_1 substitution.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Microbiol Resour Announc Year: 2020 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Microbiol Resour Announc Year: 2020 Document type: Article Affiliation country: Estados Unidos