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5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity.
Ruan, Qiu T; Yazdani, Neema; Reed, Eric R; Beierle, Jacob A; Peterson, Lucy P; Luttik, Kimberly P; Szumlinski, Karen K; Johnson, William E; Ash, Peter E A; Wolozin, Benjamin; Bryant, Camron D.
Affiliation
  • Ruan QT; Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, Boston, MA, USA.
  • Yazdani N; Biomolecular Pharmacology Training Program, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
  • Reed ER; Transformative Training Program in Addiction Science, Boston University School of Medicine, Boston, MA, USA.
  • Beierle JA; Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, Boston, MA, USA.
  • Peterson LP; Biomolecular Pharmacology Training Program, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
  • Luttik KP; Transformative Training Program in Addiction Science, Boston University School of Medicine, Boston, MA, USA.
  • Szumlinski KK; Ph.D. Program in Bioinformatics, Boston University, Boston, MA, USA.
  • Johnson WE; Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, Boston, MA, USA.
  • Ash PEA; Biomolecular Pharmacology Training Program, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
  • Wolozin B; Transformative Training Program in Addiction Science, Boston University School of Medicine, Boston, MA, USA.
  • Bryant CD; Biomolecular Pharmacology Training Program, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
FASEB J ; 34(7): 9223-9244, 2020 07.
Article in En | MEDLINE | ID: mdl-32401417

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Drug Resistance / Exons / 5' Untranslated Regions / Heterogeneous-Nuclear Ribonucleoproteins / Methamphetamine / Motor Activity Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2020 Document type: Article Affiliation country: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Drug Resistance / Exons / 5' Untranslated Regions / Heterogeneous-Nuclear Ribonucleoproteins / Methamphetamine / Motor Activity Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2020 Document type: Article Affiliation country: Estados Unidos