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Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors.
Schalper, Kurt A; Carleton, Michael; Zhou, Ming; Chen, Tian; Feng, Ye; Huang, Shu-Pang; Walsh, Alice M; Baxi, Vipul; Pandya, Dimple; Baradet, Timothy; Locke, Darren; Wu, Qiuyan; Reilly, Timothy P; Phillips, Penny; Nagineni, Venkata; Gianino, Nicole; Gu, Jianlei; Zhao, Hongyu; Perez-Gracia, Jose Luis; Sanmamed, Miguel F; Melero, Ignacio.
Affiliation
  • Schalper KA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. kurt.schalper@yale.edu.
  • Carleton M; Department of Translational Medicine, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Zhou M; Department of Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Chen T; Department of Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Feng Y; Department of Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Huang SP; Department of Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Walsh AM; Department of Translational Bioinformatics, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Baxi V; Department of Translational Bioinformatics, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Pandya D; Department of Research and Early Development, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Baradet T; Department of Translational Medicine, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Locke D; Department of Translational Medicine, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Wu Q; Department of Research and Early Development, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Reilly TP; Department of Research and Early Development, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Phillips P; Department of Translational Medicine, Bristol-Myers Squibb, Princeton, NJ, USA.
  • Nagineni V; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
  • Gianino N; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
  • Gu J; Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.
  • Zhao H; Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.
  • Perez-Gracia JL; Oncology Department, Clinica Universidad de Navarra, Pamplona, Spain.
  • Sanmamed MF; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
  • Melero I; Oncology Department, Clinica Universidad de Navarra, Pamplona, Spain.
Nat Med ; 26(5): 688-692, 2020 05.
Article in En | MEDLINE | ID: mdl-32405062
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-8 / Protein Kinase Inhibitors / Biomarkers, Pharmacological / Antineoplastic Agents, Immunological / Neoplasms / Neutrophils Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-8 / Protein Kinase Inhibitors / Biomarkers, Pharmacological / Antineoplastic Agents, Immunological / Neoplasms / Neutrophils Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos