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Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.
Nakamura, Ryoki; Numata, Tomohiro; Kasuya, Go; Yokoyama, Takeshi; Nishizawa, Tomohiro; Kusakizako, Tsukasa; Kato, Takafumi; Hagino, Tatsuya; Dohmae, Naoshi; Inoue, Masato; Watanabe, Kengo; Ichijo, Hidenori; Kikkawa, Masahide; Shirouzu, Mikako; Jentsch, Thomas J; Ishitani, Ryuichiro; Okada, Yasunobu; Nureki, Osamu.
Affiliation
  • Nakamura R; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Numata T; Department of Physiology, Graduate School of Medical Sciences, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka, Japan.
  • Kasuya G; Division of Integrative Physiology, Department of Physiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, Japan. gokasuya@jichi.ac.jp.
  • Yokoyama T; Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-shi, Kanagawa, Japan.
  • Nishizawa T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Kusakizako T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Kato T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Hagino T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Dohmae N; Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako-shi, Saitama, Japan.
  • Inoue M; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Watanabe K; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Ichijo H; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Kikkawa M; Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Shirouzu M; Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-shi, Kanagawa, Japan.
  • Jentsch TJ; Physiology and Pathology of Ion Transport, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Max-Delbrück-Centrum für Molekulare Medizin, D-13125, Berlin, Germany.
  • Ishitani R; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
  • Okada Y; Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan. okada@nips.ac.jp.
  • Nureki O; Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan. okada@nips.ac.jp.
Commun Biol ; 3(1): 240, 2020 05 15.
Article in En | MEDLINE | ID: mdl-32415200
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Ion Transport Language: En Journal: Commun Biol Year: 2020 Document type: Article Affiliation country: Japón Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Ion Transport Language: En Journal: Commun Biol Year: 2020 Document type: Article Affiliation country: Japón Country of publication: Reino Unido