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A simple method for determining compound affinity and chemical yield from DNA-encoded library selections.
Hall, Justin; Foley, Timothy L; Chen, Qiuxia; Israel, David I; Xu, Yanshan; Ford, Kristin K; Xie, Ping; Fan, Jing; Wan, Jinqiao.
Affiliation
  • Hall J; Structural Biology, Pfizer, 3200 Walnut Rd, Boulder, CO, 80301, USA. Electronic address: justin.hall@pfizer.com.
  • Foley TL; Discovery Sciences, Pfizer, Eastern Point Rd, Groton, CT, 06340, USA.
  • Chen Q; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China.
  • Israel DI; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China.
  • Xu Y; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China.
  • Ford KK; Discovery Sciences, Pfizer, Eastern Point Rd, Groton, CT, 06340, USA.
  • Xie P; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China.
  • Fan J; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China.
  • Wan J; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China.
Biochem Biophys Res Commun ; 527(1): 250-256, 2020 06 18.
Article in En | MEDLINE | ID: mdl-32446376
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / DNA / Gene Library / Cell Cycle Proteins / Combinatorial Chemistry Techniques / Rho-Associated Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / DNA / Gene Library / Cell Cycle Proteins / Combinatorial Chemistry Techniques / Rho-Associated Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article Country of publication: Estados Unidos