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Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.
Pierrillas, Philippe B; Henin, Emilie; Ogier, Julien; Amiel, Magali; Kraus-Berthier, Laurence; Chenel, Marylore; Bouzom, François; Tod, Michel.
Affiliation
  • Pierrillas PB; EMR 3738, Ciblage Thérapeutique en Oncologie, Faculté de Médecine et de Maïeutique Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, 69600, Oullins, France. philippe.pierrillas@gmail.com.
  • Henin E; Centre de Pharmacocinétique et Métabolisme, Technologie Servier, Orléans, France. philippe.pierrillas@gmail.com.
  • Ogier J; Faculté de Médecine & Maïeutique Lyon Sud Charles Mérieux, 165 chemin du Grand Revoyet - BP 12, 69921, Oullins cedex, France. philippe.pierrillas@gmail.com.
  • Amiel M; EMR 3738, Ciblage Thérapeutique en Oncologie, Faculté de Médecine et de Maïeutique Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, 69600, Oullins, France.
  • Kraus-Berthier L; Calvagone, Liergues, France.
  • Chenel M; Clinical Pharmacokinetics and Pharmacometrics Division, Servier, Paris, France.
  • Bouzom F; Translational DMPK & Safety, IPSEN Innovation 5 avenue du Canada, ZI Courtaboeuf, Les Ulis, France.
  • Tod M; Clinical Pharmacokinetics and Pharmacometrics Division, Servier, Paris, France.
Invest New Drugs ; 38(6): 1796-1806, 2020 12.
Article in En | MEDLINE | ID: mdl-32451663
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-bcl-2 / Models, Biological / Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Invest New Drugs Year: 2020 Document type: Article Affiliation country: Francia Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-bcl-2 / Models, Biological / Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Invest New Drugs Year: 2020 Document type: Article Affiliation country: Francia Country of publication: Estados Unidos