Design, Synthesis and Evaluation of the Biological Activities of Some New Carbohydrazide and Urea Derivatives.
Turk J Pharm Sci
; 15(3): 304-308, 2018 Dec.
Article
in En
| MEDLINE
| ID: mdl-32454674
ABSTRACT
OBJECTIVES:
Urea and carbohydrazide derivatives are important compounds exhibiting cytotoxic activities. In this study, a series of new urea and carbohydrazide derivatives containing an pyridine ring were synthesized and evaluated for cytotoxic activity. MATERIALS ANDMETHODS:
The proposed structures of the synthesized compounds were confirmed using elemental analysis, IR, and 1H-NMR spectroscopic techniques. The cytotoxic potencies of synthesized compounds were determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) on BRCA mutant-carrying HCC1937 and Capan-1 cell lines, as well as on MCF7, HeLa, and MRC5 cells.RESULTS:
3a, 3b, 3c and 3d showed cytotoxic activity against all cancer cell lines.CONCLUSION:
Our data indicate that compounds 3a-d are more selective to cancer cells compared with nontumoral fibroblasts; however, these compounds are not more potent on HR defective cells with BRCA mutants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Turk J Pharm Sci
Year:
2018
Document type:
Article
Affiliation country:
Turquía