Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk.
J Aging Health
; 32(9): 1267-1274, 2020 10.
Article
in En
| MEDLINE
| ID: mdl-32456512
ABSTRACT
Objective:
We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function.Method:
We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviation over each person's repeated measurements.Results:
Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (ß [95% confidence interval] [CI] = -4.39 [-7.36, -1.43], p = .004), immediate recall on the 15-Picture Learning Test (ß [95% CI] = -0.98 [-1.86, -0.11], p = .027), and delayed recall on the 15-Picture Learning Test (ß [95% CI] = -1.90 [-3.14, -0.67], p = .002). The associations did not vary by treatment group.Discussion:
Our findings suggest that variability in HDL-c may be associated with poor cognitive function among older adults.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cognition
/
Cognition Disorders
/
Cholesterol, HDL
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Aging Health
Journal subject:
GERIATRIA
Year:
2020
Document type:
Article
Affiliation country:
Francia