An aberrantly sustained emergency granulopoiesis response accelerates postchemotherapy relapse in <i>MLL1</i>-rearranged acute myeloid leukemia in mice.

Wang, Hao; Shah, Chirag A; Hu, Liping; Huang, Weiqi; Platanias, Leonidas C; Eklund, Elizabeth A

An aberrantly sustained emergency granulopoiesis response accelerates postchemotherapy relapse in MLL1-rearranged acute myeloid leukemia in mice.

Wang, Hao; Shah, Chirag A; Hu, Liping; Huang, Weiqi; Platanias, Leonidas C; Eklund, Elizabeth A.

Affiliation

Wang H; Department of Medicine, Northwestern University, Chicago, Illinois, USA.
Shah CA; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA.
Hu L; Department of Medicine, Northwestern University, Chicago, Illinois, USA.
Huang W; Department of Medicine, Northwestern University, Chicago, Illinois, USA.
Platanias LC; Department of Medicine, Northwestern University, Chicago, Illinois, USA.
Eklund EA; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA.

J Biol Chem ; 295(28): 9663-9675, 2020 07 10.

Article in En | MEDLINE | ID: mdl-32467231

Subject(s)
Key words

E3 ubiquitin ligase; TRIAD1; cancer chemotherapy; emergency granulopoiesis; gene regulation; innate immunity; kinase signaling; leukemia; mixed lineage leukemia (MLL); receptor tyrosine kinase (RTK); ubiquitin ligase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Rearrangement / Leukemia, Myeloid, Acute / Histone-Lysine N-Methyltransferase / Leukopoiesis / Myeloid-Lymphoid Leukemia Protein / Neoplasms, Experimental Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2020 Document type: Article Affiliation country: Estados Unidos

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