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N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity.
Keenan, Bryce; Finol-Urdaneta, Rocio K; Hope, Ashleigh; Bremner, John B; Kavallaris, Maria; Lucena-Agell, Daniel; Oliva, María Ángela; Díaz, Jose Fernando; Vine, Kara L.
Affiliation
  • Keenan B; 1School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Northfields Ave, Wollongong, NSW Australia.
  • Finol-Urdaneta RK; Illawarra Health and Medical Research Institute, Northfields Ave, Wollongong, NSW 2522 Australia.
  • Hope A; Illawarra Health and Medical Research Institute, Northfields Ave, Wollongong, NSW 2522 Australia.
  • Bremner JB; Electrophysiology Facility for Cell Phenotyping and Drug Discovery, Wollongong, NSW Australia.
  • Kavallaris M; 1School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Northfields Ave, Wollongong, NSW Australia.
  • Lucena-Agell D; 1School of Chemistry and Molecular Bioscience, Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Northfields Ave, Wollongong, NSW Australia.
  • Oliva MÁ; Illawarra Health and Medical Research Institute, Northfields Ave, Wollongong, NSW 2522 Australia.
  • Díaz JF; 4Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW Australia.
  • Vine KL; 5ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, UNSW, Sydney, NSW Australia.
Cancer Cell Int ; 20: 170, 2020.
Article in En | MEDLINE | ID: mdl-32467666
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancer Cell Int Year: 2020 Document type: Article Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancer Cell Int Year: 2020 Document type: Article Country of publication: Reino Unido