Your browser doesn't support javascript.
loading
Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing.
Biswas, Chayanika; Wang, Qinning; van Hal, Sebastiaan J; Eyre, David W; Hudson, Bernard; Halliday, Catriona L; Mazsewska, Krystyna; Kizny Gordon, Alice; Lee, Andie; Irinyi, Laszlo; Heath, Christopher H; Chakrabarti, Arunaloke; Govender, Nelesh P; Meyer, Wieland; Sintchenko, Vitali; Chen, Sharon C-A.
Affiliation
  • Biswas C; Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, The University of Sydney, Sydney, Australia.
  • Wang Q; Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Sydney, Australia.
  • van Hal SJ; Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, The University of Sydney, Sydney, Australia.
  • Eyre DW; Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Sydney, Australia.
  • Hudson B; Deparment of Infectious Diseases and Microbiology, New South Wales Health Pathology, The Royal Prince Alfred Hospital, Sydney, Australia.
  • Halliday CL; Big Data Institute, University of Oxford, Oxford, United Kingdom.
  • Mazsewska K; Department of Microbiology, Royal North Shore Hospital, New South Wales Health Pathology, Sydney, Australia.
  • Kizny Gordon A; Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Sydney, Australia.
  • Lee A; Marie Bashir Institute for Emerging Infections and Biosecurity, The University of Sydney, Sydney, Australia.
  • Irinyi L; Marie Bashir Institute for Emerging Infections and Biosecurity, The University of Sydney, Sydney, Australia.
  • Heath CH; Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Faculty of Medicine and Health, Westmead Clinical School and the Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
  • Chakrabarti A; Department of Microbiology, Royal North Shore Hospital, New South Wales Health Pathology, Sydney, Australia.
  • Govender NP; Deparment of Infectious Diseases and Microbiology, New South Wales Health Pathology, The Royal Prince Alfred Hospital, Sydney, Australia.
  • Meyer W; Marie Bashir Institute for Emerging Infections and Biosecurity, The University of Sydney, Sydney, Australia.
  • Sintchenko V; Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Faculty of Medicine and Health, Westmead Clinical School and the Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
  • Chen SC; Department of Microbiology, Fiona Stanley Hospital Network, PathWest Laboratory Medicine, and the Department of Infectious Diseases, Fiona Stanley Hospital, Perth, Australia.
Open Forum Infect Dis ; 7(5): ofaa158, 2020 May.
Article in En | MEDLINE | ID: mdl-32500091
ABSTRACT
Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Open Forum Infect Dis Year: 2020 Document type: Article Affiliation country: Australia
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Open Forum Infect Dis Year: 2020 Document type: Article Affiliation country: Australia