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Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats.
Kamiya, Yusuke; Otsuka, Shohei; Miura, Tomonori; Yoshizawa, Manae; Nakano, Ayane; Iwasaki, Miyu; Kobayashi, Yui; Shimizu, Makiko; Kitajima, Masato; Shono, Fumiaki; Funatsu, Kimito; Yamazaki, Hiroshi.
Affiliation
  • Kamiya Y; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
  • Otsuka S; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
  • Miura T; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
  • Yoshizawa M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
  • Nakano A; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
  • Iwasaki M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
  • Kobayashi Y; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
  • Shimizu M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
  • Kitajima M; Fujitsu Kyusyu Systems, Higashi-hie, Hakata-ku, Fukuoka 812-0007, Japan.
  • Shono F; Department of Chemical System Engineering, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Funatsu K; Department of Chemical System Engineering, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
Chem Res Toxicol ; 33(7): 1736-1751, 2020 07 20.
Article in En | MEDLINE | ID: mdl-32500706
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Pharmaceutical Preparations / Kidney / Liver / Models, Biological Type of study: Prognostic_studies Limits: Animals Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2020 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Pharmaceutical Preparations / Kidney / Liver / Models, Biological Type of study: Prognostic_studies Limits: Animals Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2020 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos