[The Clinical, Pathological, and Genetic Correlation in Frontotemporal Lobar Degeneration].
Brain Nerve
; 72(6): 575-583, 2020 Jun.
Article
in Ja
| MEDLINE
| ID: mdl-32507756
ABSTRACT
Frontotemporal lobar degeneration (FTLD) presents diverse clinical symptoms, including psychiatric, behavioral, and language symptoms. Pathologically, it is a collective term of heterogeneous neurodegenerative disorders characterized by deposits of aberrant proteins, including tau, TAR DNA-binding protein of 43kDa (TDP-43), and fused in sarcoma (FUS), predominately in frontotemporal lobes. Recent genetic research has identified several causal and susceptibility genes of FTLD. Moreover, there is an emerging correlation between the clinical-pathological phenotypes and genetic factors. Such knowledge would contribute to further clarification of the pathogenesis of FTLD and the development of novel therapeutic interventions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Frontotemporal Lobar Degeneration
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
Ja
Journal:
Brain Nerve
Journal subject:
CEREBRO
/
NEUROLOGIA
Year:
2020
Document type:
Article