Effects of soy isoflavones on serum lipids and lipoprotein (a) in peritoneal dialysis patients.
Nutr Metab Cardiovasc Dis
; 30(8): 1382-1388, 2020 07 24.
Article
in En
| MEDLINE
| ID: mdl-32513581
ABSTRACT
BACKGROUND AND AIM:
Lipid abnormalities are common in peritoneal dialysis (PD) patients and no effective treatment to decrease serum lipoprotein (a) [Lp(a)] in dialysis patients is known so far. Therefore, this research was designed to investigate the effects of soy isoflavone supplement on serum lipids and Lp(a) in PD patients. METHODS &RESULTS:
In this randomized, double-blind, placebo-controlled trial, 40 PD patients were randomly assigned to either the isoflavone or the placebo group. The patients in the isoflavone group received 100 mg soy isoflavone daily for 8 weeks, whereas the placebo group received corresponding placebos. At baseline and the end of the 8th week, 7 mL of blood was obtained from each patient and serum triglycerides, total cholesterol, low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), and Lp(a) were measured. Serum Lp(a) reduced significantly up to 10% in the isoflavone group at the end of week 8 compared to baseline (P < 0.05), and the reduction was significant in comparison with the placebo group (P < 0.05). Serum HDL-C increased significantly up to 11.5% in the isoflavone group at the end of week 8 compared to baseline (P = 0.05), and the increment was significant in comparison with the placebo group (P < 0.05). There were no significant differences between the two groups in mean changes of serum triglycerides, total cholesterol, and LDL-C.CONCLUSIONS:
This study indicates that daily administration of 100 mg soy isoflavones reduces serum Lp(a) and increases HDL-C concentration which are two determinants of cardiovascular disease in PD patients. CLINICALTRIALS.GOV NCT03773029. REGISTRATION NUMBER AND DATE NCT03773029 - 2018.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glycine max
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Peritoneal Dialysis, Continuous Ambulatory
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Lipoprotein(a)
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Dietary Supplements
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Isoflavones
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Kidney Diseases
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Cholesterol, HDL
Type of study:
Clinical_trials
/
Diagnostic_studies
Limits:
Female
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Humans
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Male
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Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Nutr Metab Cardiovasc Dis
Journal subject:
ANGIOLOGIA
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CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
/
METABOLISMO
Year:
2020
Document type:
Article