Role of Serotonin Transporter in Eye Development of Drosophila melanogaster.
Int J Mol Sci
; 21(11)2020 Jun 08.
Article
in En
| MEDLINE
| ID: mdl-32521639
ABSTRACT
Serotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in Drosophila melanogaster. We found that SerT knockdown led to excessive cell death and an increased number of cells in S-phase in the posterior eye imaginal disc. Furthermore, the knockdown of SerT in the eye disc suppressed the activation of Akt, and the introduction of PI3K effectively rescued this phenotype. These results suggested that SerT plays a role in the healthy eye development of D. melanogaster by controlling cell death through the regulation of the PI3K/Akt pathway.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organogenesis
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Drosophila melanogaster
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Proto-Oncogene Proteins c-akt
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Serotonin Plasma Membrane Transport Proteins
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Eye
Limits:
Animals
Language:
En
Journal:
Int J Mol Sci
Year:
2020
Document type:
Article
Affiliation country:
Japón