Superficial peroneal neuromodulation of nonobstructive urinary retention in cats.
Neurourol Urodyn
; 39(6): 1679-1686, 2020 08.
Article
in En
| MEDLINE
| ID: mdl-32542996
ABSTRACT
AIMS:
To determine if superficial peroneal nerve stimulation (SPNS) can improve nonobstructive urinary retention (NOUR).METHODS:
In α-chloralose anesthetized cats, NOUR was induced by repetitive application (4-16 times) of 30-minute tibial nerve stimulation (TNS 5 Hz frequency, 0.2 ms pulse width) at 4 to 6 times threshold intensity (T) for inducing toe twitches. SPNS (1 Hz, 0.2 ms) at 2 to 4 times threshold intensity (T) for inducing posterior thigh muscle contractions was applied either continuously (SPNSc) during a cystometrogram (CMG) or during voiding (SPNSv) by a surgically implanted cuff electrode or by skin surface electrodes to determine if the stimulation reduced NOUR induced by prolonged TNS.RESULTS:
During control CMGs, efficient (86.4% ± 5.5%) voiding occurred with a postvoid residual (PVR) volume equal to 14.9% ± 6.2% of control bladder capacity. NOUR elicited by prolonged TNS significantly (P < .05) increased bladder capacity to 168.6% ± 15.5% of control, reduced voiding efficiency to 30.4% ± 4.8%, and increased PVR to 109% ± 9.2% of control. Using the implanted cuff electrode, SPNSc and SPNSv significantly (P < .05) increased voiding efficiency to 66.7% ± 7.4% and 65.0% ± 5.9%, respectively, and reduced PVR to 52.2% ± 11.4% and 64.3% ± 11.6%, respectively. SPNSc but not SPNSv significantly (P < .05) reduced bladder capacity to 133.4% ± 15% of control. Transcutaneous SPNSv but not SPNSc also significantly (P < .05) reversed the TNS-induced NOUR responses.CONCLUSIONS:
This study shows that SPNS is effective in reversing NOUR induced by prolonged TNS. Transcutaneous SPNS provides the opportunity to develop a noninvasive neuromodulation therapy for NOUR to treat more patients than current sacral neuromodulation therapy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peroneal Nerve
/
Reflex
/
Urination
/
Electric Stimulation Therapy
/
Urinary Retention
Limits:
Animals
Language:
En
Journal:
Neurourol Urodyn
Year:
2020
Document type:
Article