Corneal penetration of rifampin.
Am J Ophthalmol
; 83(6): 862-5, 1977 Jun.
Article
in En
| MEDLINE
| ID: mdl-326055
We tested the corneal penetration of rifampin in four vehicles: dimethylsulfoxide, polyethylene glycol, an ocular lubricant, and as rifampin ointment. We measured drug concentrations in the aqueous humor in rabbits after topical instillation of 1 and 2.5% rifampin according to two dosage schedules. Drug concentrations in the aqueous humor were bactericidal to Mycobacterium leprae. Since leprosy of the cornea, iris, and ciliary body may develop despite standard systemic bacteriostatic treatment, treatment of leprotic involvement of the anterior eye may be enhanced by intensive topical application of rifampin.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rifampin
/
Cornea
Limits:
Animals
Language:
En
Journal:
Am J Ophthalmol
Year:
1977
Document type:
Article
Country of publication:
Estados Unidos