Cortical Morphometry is Associated with Neuropsychological Function in Healthy 8-Year-Old Children.
J Neuroimaging
; 30(6): 833-842, 2020 11.
Article
in En
| MEDLINE
| ID: mdl-32639653
ABSTRACT
BACKGROUND AND PURPOSE:
Cortical development is essential for children's neurocognition. In this study, we evaluated how variations in cortical morphometry in normal children are associated with outcome differences in multiple domains of cognition.METHODS:
Eight-year-old children were recruited for a brain MRI followed by a battery of neuropsychological assessments. The MRI scan included 3D-T1-weighted imaging for cortical morphometry in 34 regions defined by the Desikan atlas. The neuropsychological assessments included the Reynolds Intellectual Assessment Scales (RIAS) for IQ, Clinical Evaluation of Language Fundamentals (CELF-4) for language, Children's Memory Scale (CMS) for memory, Wide Range Achievement Test (WRAT-4) for academic skills, and Behavior Rating Inventory of Executive Function (BRIEF) for executive functions. The relationships between MRI measured cortical features, including gray matter volume, surface area, and cortical thickness for different brain regions and neuropsychological test scores, were evaluated using partial correlation analyses controlled for age and sex.RESULTS:
RIAS/CELF-4/CMS/WRAT-4/BRIEF scores showed significant correlations (R [.38-.44], P [.005-.046]) with gray matter volume, surface area, or cortical thickness in multiple brain regions. Gray matter volume in the medial orbitofrontal/ventromedial prefrontal cortex appeared to be a sensitive marker for overall neurocognition as it significantly correlated with IQ, language, memory, and executive function behaviors. The superior temporal gyrus and banks of superior temporal sulcus appeared to be most sensitive to reflect overall language function as their cortical features consistently correlated with language-related test scores.CONCLUSIONS:
Cortical morphometry significantly correlated with neuropsychological function in healthy children; certain regions/features may serve as sensitive imaging markers.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Cognition
/
Executive Function
/
Gray Matter
Type of study:
Risk_factors_studies
Limits:
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Neuroimaging
Journal subject:
DIAGNOSTICO POR IMAGEM
/
NEUROLOGIA
Year:
2020
Document type:
Article
Affiliation country:
Argentina