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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
Mok, Beverly Y; de Moraes, Marcos H; Zeng, Jun; Bosch, Dustin E; Kotrys, Anna V; Raguram, Aditya; Hsu, FoSheng; Radey, Matthew C; Peterson, S Brook; Mootha, Vamsi K; Mougous, Joseph D; Liu, David R.
Affiliation
  • Mok BY; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • de Moraes MH; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
  • Zeng J; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
  • Bosch DE; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, USA.
  • Kotrys AV; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, USA.
  • Raguram A; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, USA.
  • Hsu F; Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
  • Radey MC; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Peterson SB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Mootha VK; Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warsaw, Poland.
  • Mougous JD; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Liu DR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Nature ; 583(7817): 631-637, 2020 07.
Article in En | MEDLINE | ID: mdl-32641830
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Toxins / DNA, Mitochondrial / Cytidine Deaminase / Genes, Mitochondrial / Gene Editing / Mitochondria Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nature Year: 2020 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Toxins / DNA, Mitochondrial / Cytidine Deaminase / Genes, Mitochondrial / Gene Editing / Mitochondria Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nature Year: 2020 Document type: Article Affiliation country: Estados Unidos